J.E. McPherson – A Career of Exemplary Service and Contributions to the Entomological Society of America

(excerpt) Scientific societies are a vital component of the infrastructure that fosters progress in science. They play a vital role in the exchange of information through the publication of scientific journals and by organizing scientific meetings and symposia at which results and ideas are shared and discussed, professional contacts are made, and networks established and maintained. Scientific societies provide a plethora of professional development opportunities for both young and established scientists. They are volunteer organizations comprised of and led by practicing scientists, teachers, and practitioners who provide the vision, leadership, governance, scientific and ethical standards, scientific programming, and educational training opportunities that lie at the core of their mission. Exceptional service to scientific societies is often a hallmark of outstanding scientists and educators. It is therefore no surprise that outstanding service to the Entomological Society of America (ESA) spanning over 30 years is a hallmark of J. E. (Jay) McPherson’s career (Fig. 1)

Temperature and Precipitation Affect Seasonal Patterns of Dispersing Tobacco Thrips, Frankliniella fusca, and Onion Thrips, Thrips tabaci (Thysanoptera: Thripidae) Caught on Sticky Traps

Effects of temperature and precipitation on the temporal patterns of dispersing tobacco thrips, Frankliniella fusca, and onion thrips, Thrips tabaci, caught on yellow sticky traps were estimated in central and eastern North Carolina and eastern Virginia from 1997 through 2001. The impact that these environmental factors had on numbers of F. fusca and T. tabaci caught on sticky traps during April and May was determined using stepwise regression analysis of 43 and 38 site-years of aerial trapping data from 21 and 18 different field locations, respectively. The independent variables used in the regression models included degree-days, total precipitation, and the number of days in which precipitation occurred during January through May. Each variable was significant in explaining variation for both thrips species and, in all models, degree-days was the single best explanatory variable. Precipitation had a comparatively greater effect on T. tabaci than F. fusca. The numbers of F. fusca and T. tabaci captured in flight were positively related to degree-days and the number of days with precipitation but negatively related to total precipitation. Combined in a single model, degree-days, total precipitation, and the number of days with precipitation explained 70 and 55% of the total variation in the number of F. fusca captured from 1 April through 10 May and from 1 April through 31 May, respectively. Regarding T. tabaci flights, degree-days, total precipitation, and the number of days with precipitation collectively explained 57 and 63% of the total variation in the number captured from 1 April through 10 May and from 1 April through 31 May, respectivel

A thrips vector of tomato spotted wilt virus responds to tomato acylsugar chemical diversity with reduced oviposition and virus inoculation.

There is increasing evidence that acylsugars deter insect pests and plant virus vectors, including the western flower thrips (WFT), Frankliniella occidentalis (Pergande), vector of tomato spotted wilt virus (TSWV). Acylsugars are sugar-polyesters composed of saturated, un-saturated, and variously branched short and long chain fatty acids (FAs) esterified to a glucose (acylglucose) or sucrose (acylsucrose) moiety. We sought to understand how acylsucrose amount and composition of associated FA profiles interacted to mediate resistance to WFT oviposition and TSWV inoculation on tomato leaves. Towards this goal, we examined WFT oviposition and TSWV inoculation behavior on tomato lines bred to exude varying amounts of acylsucrose in association with diverse FA profiles. Our data show that as acylsucrose amounts increased, WFT egg-laying (oviposition) decreased and TSWV inoculation was suppressed. Western flower thrips also responded to FA profiles that included iC4, iC11, nC12 and nC10 FA. These findings support improving acylsugar-mediated resistance against WFT by breeding tomatoes exuding greater amounts of acylsucrose associated with specific FA profiles. We show that increasing acylsucrose amount output by type IV trichomes and selecting for particular FA profiles through advanced breeding profoundly affects WFT behavior in ways that benefit management of WFT as direct pests and as TSWV vectors

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis

Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is invariably fatal if untreated. There are 60 million people at risk from the disease throughout sub-Saharan Africa. The infection progresses from the haemolymphatic stage where parasites invade the blood, lymphatics and peripheral organs, to the late encephalitic stage where they enter the central nervous system (CNS) to cause serious neurological disease. The trivalent arsenical drug melarsoprol (Arsobal) is the only currently available treatment for CNS-stage <i>T.b.rhodesiense</i> infection. However, it must be administered intravenously due to the presence of propylene glycol solvent and is associated with numerous adverse reactions. A severe post-treatment reactive encephalopathy occurs in about 10% of treated patients, half of whom die. Thus melarsoprol kills 5% of all patients receiving it. Cyclodextrins have been used to improve the solubility and reduce the toxicity of a wide variety of drugs. We therefore investigated two melarsoprol cyclodextrin inclusion complexes; melarsoprol hydroxypropyl-͎-cyclodextrin and melarsoprol randomly-methylated-β-cyclodextrin. We found that these compounds retain trypanocidal properties <i>in vitro</i> and cure CNS-stage murine infections when delivered orally, once per day for 7-days, at a dosage of 0.05 mmol/kg. No overt signs of toxicity were detected. Parasite load within the brain was rapidly reduced following treatment onset and magnetic resonance imaging showed restoration of normal blood-brain barrier integrity on completion of chemotherapy. These findings strongly suggest that complexed melarsoprol could be employed as an oral treatment for CNS-stage HAT, delivering considerable improvements over current parenteral chemotherapy

Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers

Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity

Magnetic Resonance Imaging to Assess Blood–Brain Barrier Damage in Murine Trypanosomiasis

The ability of trypanosomes to invade the brain and induce an inflammatory reaction is well-recognized. This study uses magnetic resonance imaging (MRI) in conjunction with a murine model of central nervous system (CNS) stage trypanosomiasis to investigate this phenomenon at the level of the blood–brain barrier (BBB). Mice were scanned before and after administration of the contrast agent. Signal enhancement maps were generated, and the percentage signal change was calculated. The severity of the neuroinflammation was also assessed. Statistical analysis of the signal change data revealed a significantly (P = 0.028) higher signal enhancement in mice at 28 days post-infection (least squares mean = 26.709) compared with uninfected animals (6.298), indicating the presence of BBB impairment. Leukocytes were found in the meninges and perivascular space of some blood vessels in the infected mice. This study shows that the integrity of the BBB is compromised during CNS stage trypanosomiasis and that the impairment does not correlate with inflammatory cell infiltration

Reproductive Modes in Onion Thrips (Thysanoptera: Thripidae) Populations from New York Onion Fields

Thrips exhibit different reproductive modes including thelytoky (females produced from unfertilized eggs), arrhenotoky (males produced from unfertilized eggs and females produced from fertilized eggs) and deuterotoky (females and males produced from unfertilized eggs). We investigated patterns of reproductive modes in onion thrips, Thrips tabaci Lindeman, populations and potential effects of the bacterium Wolbachia and temperature on these modes. We also examined the possibility that male-producing T. tabaci populations were resistant to the frequently used insecticides, lambda-cyhalothrin and methomyl. In New York during 2002-2004, T. tabaci populations were sampled from 20 onion fields and reproductive mode was determined by identifying sex of progeny from virgins. Half of the populations were thelytokous and half were a mix of thelytokous, arrhenotokous and deuterotokous individuals, which we refer to as a male-producing population. In two of four cases, the reproductive mode of a population from the same onion field changed across years, suggesting that populations either mix or an external factor caused the change. To address the latter, we speculated that Wolbachia or high temperature mediated reproductive modes. Samples of T. tabaci representing each reproductive mode were examined for Wolbachia using diagnostic polymerase chain reaction (PCR), but it was not detected. Cytological examination of ovaries from two additional thelytokous lines also showed no evidence of Wolbachia. Similarly, high temperature did not affect sex allocation ratios in either thelytokous or male-producing populations. Male-producing T. tabaci populations were not positively correlated with resistance to lambda-cyhalothrin, or tolerance to methomyl. The role of the different reproductive modes in T. tabaci populations in onion fields remains unclea

Status of the QCDSP project

We describe the completed 8,192-node, 0.4Tflops machine at Columbia as well as the 12,288-node, 0.6Tflops machine assembled at the RIKEN Brookhaven Research Center. Present performance as well as our experience in commissioning these large machines is presented. We outline our on-going physics program and explain how the configuration of the machine is varied to support a wide range of lattice QCD problems, requiring a variety of machine sizes. Finally a brief discussion is given of future prospects for large-scale lattice QCD machines.Comment: LATTICE98(machines), 3 pages, 1 picture, 1 figur

Planning a 'slum free' Trivandrum: housing upgrade and the rescaling of urban governance in India

This paper examines how India’s national urban development agenda is reshaping relationships between national, State and city-level governments. JNNURM, the flagship programme that heralded a new era of urban investment in India, contained a range of key governance aspirations: linking the analysis of urban poverty to city-level planning, developing holistic housing solutions for the urban poor, and above all empowering Urban Local Bodies to re-balance relationships between State and city-level governments in favour of the latter. Here, we trace JNNURM’s implementation in Kerala’s capital city, Trivandrum (Thiruvananthapuram), where the city’s decentralised urban governance structure and use of ‘pro-poor’ institutions to implement housing upgrade programmes could have made it an exemplar of success. In practice, Trivandrum’s ‘city visioning’ exercises and the housing projects it has undertaken have fallen short of JNNURM’s lofty goals. The contradictions between empowering cities and retaining centralised control embedded within this national programme, and the unintended city-level consequences of striving for JNNURM funding success, have reshaped urban governance in ways not envisaged within policy. As a result, JNNURM has been important in rescaling governance relationships through three interlinked dynamics of problem framing, technologies of governance and the scalar strategy of driving reform ‘from above’ that together have ensured the national state’s continued influence over the practices of urban governance in India

Performance of the NINDS-CSN 5-Minute Protocol in a National Population-Based Sample

Background In 2006, the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network (NINDS-CSN) Vascular Cognitive Impairment Harmonization Standards recommended a 5-Minute Protocol as a brief screening instrument for vascular cognitive impairment (VCI). We report demographically adjusted norms for the 5-Minute Protocol and its relation to other measures of cognitive function and cerebrovascular risk factors. Methods Cross-sectional analysis of 7,199 stroke-free adults in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study on the NINDS-CSN 5-Minute Protocol score. Results Total scores on the 5-Minute Protocol were inversely correlated with age and positively correlated with years of education, and performance on the Six-Item Screener, Word List Learning, and Animal Fluency (all p-values<0.001). Higher cerebrovascular risk on the Framingham Stroke Risk Profile (FSRP) was associated with lower total 5-Minute Protocol scores (p<0.001). The 5-Minute Protocol also differentiated between participants with and without confirmed stroke and with and without stroke symptom histories (p<0.001). Conclusions The NINDS-CSN 5-Minute Protocol is a brief, easily administered screening measure that is sensitive to cerebrovascular risk and offers a valid method of screening for cognitive impairment in populations at risk for VCI